Androgen receptor, ccl2, and epithelial-mesenchymal transition
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چکیده
منابع مشابه
Androgen receptor, ccl2, and epithelial-mesenchymal transition
High levels of chemokine (C-C motif) ligand 2 (CCL2) promote the metastatic dissemination of prostate cancer by recruiting macrophages to neoplastic lesions. We have recently discovered that inhibiting the androgen receptor (AR) in prostate cancer cells or tumor-infiltrating macrophages results in the upregulation CCL2 and promotes disease progression by activating signal transducer and activat...
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Owing to this fact that most of the mortalities in cancers are as a result of metastasis, study on the involved pathways in metastasis including Epithelial to mesenchymal transition (EMT) would be so critical and important. Up to date, several extensive studies have been carried out to determine the correlation between EMT and cancer and their results have shown that the EMT plays pivotal role ...
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ژورنال
عنوان ژورنال: OncoImmunology
سال: 2014
ISSN: 2162-402X
DOI: 10.4161/onci.27871